Testing airway responsiveness using inhaled methacholine or histamine
نویسندگان
چکیده
منابع مشابه
The relative responsiveness to inhaled leukotriene E4, methacholine and histamine in normal and asthmatic subjects.
The relative bronchoconstricting potencies of leukotriene E4 (LTE4) methacholine and histamine have been compared in asthmatic and normal subjects. LTE4 responsiveness in asthmatic subjects, as measured by the dose which produced a 35% fall in specific airways conductance (PD35), ranged from 0.06-24.4 nmol (geom mean 4.1 nmol, n = 20). This was significantly less than the PD35 in normal subject...
متن کاملDissociation between airway responsiveness to methacholine and responsiveness to antigen.
Repeated aerosolized antigen challenges to brown Norway (BN) rats generate nonspecific airway hyperresponsiveness (AHR). On the other hand, some studies have demonstrated that repeated antigen challenge could attenuate antigen-specific AHR in BN rats. The authors questioned whether such dissociation in airway responses actually occurs when assessed in a single study in the same animals. The aut...
متن کاملAirway responsiveness to histamine and methacholine: relationship to minimum treatment to control symptoms of asthma.
We have prospectively examined in 51 patients the relationship between the level of airway responsiveness to histamine and methacholine and the minimum medications required to control asthma. First we determined the least medication that was required to control symptoms so that they did not disturb sleep, were not present on waking, and did not require use of inhaled salbutamol (200 microgram) ...
متن کاملReproducibility and comparison of responses to inhaled histamine and methacholine.
The efficiency of a standardised inhalation test procedure was studied by examining the reproducibility of responses to histamine and methacholine. In addition, the responses to the two agents were compared. Each set of duplicate tests was carried out on a separate day within one week, and all factors known or presumed to influence responses were carefully controlled. The results were expressed...
متن کاملEffects of vitamin C on airway responsiveness to inhaled histamine in heavy smokers.
Histamine bronchial threshold, the provocation concentration of histamine causing a 25% fall in maximal expiratory flow at 50% of forced vital capacity from the control value (PC25MEF50), was measured in seven heavy smokers and in seven sex- and age-matched nonsmokers before and one hour after ingestion, double-blind, of vitamin C (2 g) or placebo. Smokers had significantly lower baseline value...
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ژورنال
عنوان ژورنال: Respirology
سال: 1997
ISSN: 1323-7799,1440-1843
DOI: 10.1111/j.1440-1843.1997.tb00061.x